Zhi-Wu Chen Selected Research

Urotensins

12/2019	Urotensin-#receptor antagonist SB-706375 protected isolated rat heart from ischaemia-reperfusion injury by attenuating myocardial necrosis via RhoA/ROCK/RIP3 signalling pathway.
1/2016	Urotensin-ⅡReceptor Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway.

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Zhi-Wu Chen Research Topics

Disease

16	Reperfusion Injury 10/2021 - 01/2007
9	Myocardial Ischemia (Ischemic Heart Diseases) 11/2019 - 11/2004
9	Brain Ischemia (Cerebral Ischemia) 01/2018 - 01/2008
8	Infarction (Infarctions) 02/2019 - 01/2006
5	Hypoxia (Hypoxemia) 01/2020 - 01/2008
4	Wounds and Injuries (Trauma) 11/2019 - 05/2006
4	Myocardial Infarction 11/2019 - 05/2012
3	Cerebral Infarction 01/2018 - 01/2007
2	Brain Injuries (Brain Injury) 10/2021 - 12/2015
2	Pathologic Processes 10/2020 - 12/2015
2	Necrosis 12/2019 - 05/2007
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2019 - 04/2011
2	Ischemia 02/2019 - 07/2012
2	Fibrosis (Cirrhosis) 01/2016 - 10/2008
2	Inflammation (Inflammations) 04/2013 - 02/2013
2	Burns 05/2007 - 05/2006
1	Cardiac Arrhythmias (Arrythmia) 02/2019
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2018
1	Acidosis 12/2015
1	Epilepsy (Aura) 12/2015
1	Nervous System Diseases (Neurological Disorders) 12/2015
1	Cardiomegaly (Heart Hypertrophy) 04/2013
1	Hypertrophy 02/2013
1	Hyperplasia 02/2013
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 02/2013
1	Ventricular Remodeling 02/2013
1	Parkinson Disease (Parkinson's Disease) 01/2009
1	Hepatitis 10/2008

Drug/Important Bio-Agent (IBA)

11	FlavonesIBA 01/2020 - 01/2007
7	Proteins (Proteins, Gene)FDA Link 11/2019 - 10/2008
5	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2018 - 05/2007
3	endothelium-dependent hyperpolarization factor (EDHF)IBA 10/2021 - 01/2013
3	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 10/2020 - 01/2018
3	LyasesIBA 11/2019 - 01/2018
3	CystathionineIBA 11/2019 - 01/2018
3	Malondialdehyde (Propanedial)IBA 01/2018 - 01/2008
3	salicylhydroxamic acid (SHAM)IBA 07/2012 - 05/2006
2	iberiotoxinIBA 10/2021 - 12/2015
2	UrotensinsIBA 12/2019 - 01/2016
2	Protein Kinases (Protein Kinase)IBA 11/2019 - 01/2008
2	Morphine (MS Contin)FDA LinkGeneric 02/2019 - 04/2011
2	Phosphotransferases (Kinase)IBA 07/2017 - 01/2008
2	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2016 - 01/2013
2	Creatine Kinase (Creatine Phosphokinase)IBA 01/2016 - 05/2012
2	Troponin IIBA 01/2016 - 05/2012
2	Glutathione PeroxidaseIBA 01/2015 - 01/2008
2	Superoxide DismutaseIBA 01/2015 - 01/2008
2	HydrogenIBA 01/2014 - 01/2013
2	SaponinsIBA 04/2013 - 02/2013
2	Pen(5)-Trp(7)-Orn(8)- urotensin II (4-11)IBA 05/2012 - 02/2008
2	NF-kappa B (NF-kB)IBA 10/2008 - 05/2006
2	Alanine Transaminase (SGPT)IBA 10/2008 - 05/2006
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2008 - 05/2006
2	Messenger RNA (mRNA)IBA 01/2008 - 01/2007
2	tetramethylpyrazineIBA 05/2007 - 05/2006
2	Ringer's LactateIBA 05/2007 - 05/2006
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2007 - 11/2004
1	3-mercaptopyruvate sulphurtransferaseIBA 10/2020
1	SB-706375IBA 12/2019
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 11/2019
1	TroponinIBA 02/2019
1	Small Interfering RNA (siRNA)IBA 01/2018
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2018
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2018
1	flavoneIBA 01/2018
1	prostacyclin synthetase (prostacyclin synthase)IBA 01/2018
1	Caspase 3 (Caspase-3)IBA 07/2017
1	Interleukin-6 (Interleukin 6)IBA 07/2017
1	Agkistrodon acutus agkisacucetin proteinIBA 07/2017
1	Atrial Natriuretic Factor (ANF)IBA 07/2017
1	Sufentanil (Sufenta)FDA LinkGeneric 12/2016
1	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 12/2016
1	urotensin IIIBA 01/2016
1	SB-710411IBA 01/2016
1	Acid Sensing Ion ChannelsIBA 12/2015
1	NLR ProteinsIBA 12/2015
1	CationsIBA 12/2015
1	NucleotidesIBA 12/2015
1	Interleukin-18 (Interleukin 18)IBA 12/2015
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 12/2015
1	InflammasomesIBA 12/2015
1	CatalaseIBA 01/2015
1	hyperosideIBA 01/2015
1	FlavonoidsIBA 01/2015
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2013
1	CollagenIBA 02/2013
1	sodium bisulfide (NaHS)IBA 01/2013
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2012
1	Protein Kinase CIBA 05/2012
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 05/2012
1	Dihydrotachysterol (AT 10)IBA 05/2012
1	Opioid Receptors (Opioid Receptor)IBA 04/2011
1	cilnidipineIBA 04/2011
1	UbiquitinIBA 01/2009
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2009
1	Therapeutic UsesIBA 10/2008
1	Hydroxyproline (4 Hydroxyproline)IBA 10/2008
1	Hyaluronic Acid (Hyaluronan)IBA 10/2008

Therapy/Procedure

2	Resuscitation 05/2007 - 05/2006
1	Therapeutics 04/2011